Predominant drug-resistant mutations at reverse transcriptase (RT) genes have been M184V, T215Y, M41L and V108I and H221Y although at protease (PR) genes have been M46I and I47V. One of the large-threat groups, IDUs have the highest range of drug-resistant mutations accompanied by heterosexual persons. It had been even more proven https://hivhub.in/understanding-the-hiv-situation-in-manipur-an-overview/