There is a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors while in the dorsal horn to reduce afferent pain transmission and generate analgesia. For that reason, drugs like clonidine that focus on alpha-2 receptors can affect the transmission of pain. Clonidine is an https://dicki172ukz6.sunderwiki.com/user