Introduction: Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML). with myeloid sarcoma (MS) seldom occurring at onset. Myelofibrosis (MF) is a condition characterized by megakaryocytic proliferation and atypia with an array of clinical findings. but MF secondary to APL treatment is extremely rare. https://www.rawafricaonline.com/