There's a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors while in the dorsal horn to decrease afferent pain transmission and produce analgesia. Consequently, drugs like clonidine that target alpha-2 receptors can influence the transmission of discomfort. Clonidine is dispersed in breast milk; caution https://williamn495duj1.thebindingwiki.com/user