Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals from the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific tests have determined recurrent mutations in genes regulating tumor cell-microenvironment interacti... https://chrisc936xfj8.anchor-blog.com/profile